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Active Microneedle Administration of Plant Virus Nanoparticles for Cancer in situ Vaccination Improves Immunotherapeutic Efficacy

The solid tumor microenvironment (TME) poses a significant structural and biochemical barrier to immunotherapeutic agents. To address the limitations of tumor penetration and distribution, and to enhance antitumor efficacy of immunotherapeutics, we present here an autonomous active microneedle (MN)...

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Dettagli Bibliografici
Pubblicato in:ACS Appl Nano Mater
Autori principali: Boone, Christine E., Wang, Chao, Lopez-Ramirez, Miguel Angel, Beiss, Veronique, Shukla, Sourabh, Chariou, Paul L., Kupor, Daniel, Rueda, Ricardo, Wang, Joseph, Steinmetz, Nicole F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101548/
https://ncbi.nlm.nih.gov/pubmed/33969278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsanm.0c01506
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