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Active Microneedle Administration of Plant Virus Nanoparticles for Cancer in situ Vaccination Improves Immunotherapeutic Efficacy

The solid tumor microenvironment (TME) poses a significant structural and biochemical barrier to immunotherapeutic agents. To address the limitations of tumor penetration and distribution, and to enhance antitumor efficacy of immunotherapeutics, we present here an autonomous active microneedle (MN)...

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Detalhes bibliográficos
Publicado no:ACS Appl Nano Mater
Main Authors: Boone, Christine E., Wang, Chao, Lopez-Ramirez, Miguel Angel, Beiss, Veronique, Shukla, Sourabh, Chariou, Paul L., Kupor, Daniel, Rueda, Ricardo, Wang, Joseph, Steinmetz, Nicole F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101548/
https://ncbi.nlm.nih.gov/pubmed/33969278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsanm.0c01506
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