The IgG3 subclass of β1-adrenergic receptor autoantibodies is an endogenous biaser of β1AR signaling

Dysregulation of immune responses has been linked to the generation of immunoglobulin G (IgG) autoantibodies that target human β1ARs and contribute to deleterious cardiac outcomes. Given the benefits of β-blockers observed in patients harboring the IgG3 subclass of autoantibodies, we investigated th...

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Veröffentlicht in:Mol Biol Cell
Hauptverfasser: Mohan, Maradumane L., Nagatomo, Yuji, Saha, Prasenjit Prasad, Mukherjee, Sromona D., Engelman, Timothy, Morales, Rommel, Hazen, Stanley L., Tang, W. H. Wilson, Prasad, Sathyamangla V. Naga
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2021
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101462/
https://ncbi.nlm.nih.gov/pubmed/33534612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-06-0394
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