MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD(+)-Sirt1 pathway

BACKGROUND: Expansion-mediated replicative senescence and age-related natural senescence have adverse effects on mesenchymal stem cell (MSC) regenerative capability and functionality, thus severely impairing the extensive applications of MSC-based therapies. Emerging evidences suggest that microRNA-...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Pi, Chenchen, Ma, Cao, Wang, Huan, Sun, Hui, Yu, Xiao, Gao, Xingyu, Yang, Yue, Sun, Yanan, Zhang, Haiying, Shi, Yingai, Li, Yan, Li, Yulin, He, Xu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101138/
https://ncbi.nlm.nih.gov/pubmed/33957971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02339-0
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