Enzymatically Inactive Tissue-Type Plasminogen Activator Reverses Disease Progression in the Dextran Sulfate Sodium Mouse Model of Inflammatory Bowel Disease

Enzymatically inactive tissue-type plasminogen activator (EI-tPA) does not activate fibrinolysis, but interacts with the N-methyl-d-aspartate receptor (NMDA-R) and low-density lipoprotein receptor–related protein-1 (LRP1) in macrophages to block innate immune system responses mediated by toll-like r...

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Detalles Bibliográficos
Publicado en:Am J Pathol
Autores principales: Das, Lipsa, Banki, Michael A., Azmoon, Pardis, Pizzo, Donald, Gonias, Steven L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Investigative Pathology 2021
Materias:
Short Communication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101053/
https://ncbi.nlm.nih.gov/pubmed/33465348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2021.01.001
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