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Investigations into the synthesis of a nucleotide dimer via mechanochemical phosphoramidite chemistry

Liquid-assisted mechanochemistry as a versatile approach for the coupling of a nucleoside phosphoramidite with a 5′-OH partially protected nucleoside has been investigated. Noted advantages over reported methods were a simplified reaction protocol, a drastic reduction in the use of toxic solvents, t...

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Vydáno v:R Soc Open Sci
Hlavní autoři: Johnston, C., Hardacre, C., Migaud, M. E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Royal Society 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8101013/
https://ncbi.nlm.nih.gov/pubmed/34035937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsos.201703
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