RRx-001 Radioprotection: Enhancement of Survival and Hematopoietic Recovery in Gamma-Irradiated Mice

The present studies evaluate the in vivo prophylactic radioprotective effects of 1-bromoacetyl-3, 3-dinitroazetidine (RRx-001), a phase III anticancer agent that inhibits c-myc and downregulates CD-47, after total body irradiation (TBI), in lethally and sublethally irradiated CD2F1 male mice. A sing...

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Udgivet i:Front Pharmacol
Main Authors: Jurgensen, Kimberly J., Skinner, William K. J., Oronsky, Bryan, Abrouk, Nacer D., Graff, Andrew E., Landes, Reid D., Culp, William E., Summers, Thomas A., Cary, Lynnette H.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2021
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100686/
https://ncbi.nlm.nih.gov/pubmed/33967816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.676396
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