Cryptotanshinone Inhibits ERα-Dependent and -Independent BCRP Oligomer Formation to Reverse Multidrug Resistance in Breast Cancer

Both long-term anti-estrogen therapy and estrogen receptor-negative breast cancer contribute to drug resistance, causing poor prognosis in breast cancer patients. Breast cancer resistance protein (BCRP) plays an important role in multidrug resistance. Here, we show that cryptotanshinone (CPT), an an...

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Vydáno v:Front Oncol
Hlavní autoři: Ni, Wenting, Fan, Hui, Zheng, Xiuqin, Xu, Fangming, Wu, Yuanyuan, Li, Xiaoman, Wang, Aiyun, Huang, Shile, Chen, Wenxing, Wang, Shijun, Lu, Yin
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100513/
https://ncbi.nlm.nih.gov/pubmed/33968724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.624811
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