IFNγ Modulates the Immunopeptidome of Triple Negative Breast Cancer Cells by Enhancing and Diversifying Antigen Processing and Presentation

Peptide vaccination remains a viable approach to induce T-cell mediated killing of tumors. To identify potential T-cell targets for Triple-Negative Breast Cancer (TNBC) vaccination, we examined the effect of the pro-inflammatory cytokine interferon-γ (IFNγ) on the transcriptome, proteome, and immuno...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Goncalves, Gabriel, Mullan, Kerry A., Duscharla, Divya, Ayala, Rochelle, Croft, Nathan P., Faridi, Pouya, Purcell, Anthony W.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100505/
https://ncbi.nlm.nih.gov/pubmed/33968037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.645770
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