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Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
The heterodimer of ATP-binding cassette transporter ABCG5 and ABCG8 mediates the excretion of sterols from liver and intestine, playing a critical role in cholesterol homeostasis. Here, we present the cryo-EM structure of ABCG5/G8 in complex with the Fab fragments from two monoclonal antibodies at 3...
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| Izdano u: | Commun Biol |
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| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2021
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8100176/ https://ncbi.nlm.nih.gov/pubmed/33953337 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02039-8 |
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