Mexiletine-like cellular electrophysiological effects of GS967 in canine ventricular myocardium

Enhancement of the late Na(+) current (I(NaL)) increases arrhythmia propensity in the heart, while suppression of the current is antiarrhythmic. GS967 is an agent considered as a selective blocker of I(NaL). In the present study, effects of GS967 on I(NaL) and action potential (AP) morphology were s...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Hézső, Tamás, Naveed, Muhammad, Dienes, Csaba, Kiss, Dénes, Prorok, János, Árpádffy-Lovas, Tamás, Varga, Richárd, Fujii, Erika, Mercan, Tanju, Topal, Leila, Kistamás, Kornél, Szentandrássy, Norbert, Almássy, János, Jost, Norbert, Magyar, János, Bányász, Tamás, Baczkó, István, Varró, András, Nánási, Péter P., Virág, László, Horváth, Balázs
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2021
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC8100105/
https://ncbi.nlm.nih.gov/pubmed/33953276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-88903-3
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