Tetrodotoxin Blockade on Canine Cardiac L-Type Ca(2+) Channels Depends on pH and Redox Potential

Tetrodotoxin (TTX) is believed to be one of the most selective inhibitors of voltage-gated fast Na(+) channels in excitable tissues. Recently, however, TTX has been shown to block L-type Ca(2+) current (I(Ca)) in canine cardiac cells. In the present study, the TTX-sensitivity of I(Ca) was studied in...

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Detalhes bibliográficos
Principais autores: Hegyi, Bence, Komáromi, István, Kistamás, Kornél, Ruzsnavszky, Ferenc, Váczi, Krisztina, Horváth, Balázs, Magyar, János, Bányász, Tamás, Nánási, Péter P., Szentandrássy, Norbert
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721225/
https://ncbi.nlm.nih.gov/pubmed/23771047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md11062140
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