Patient-derived orthotopic xenograft models of medulloblastoma lack a functional blood-brain barrier

BACKGROUND: Novel targeted therapies for children diagnosed with medulloblastoma (MB), the most common malignant pediatric brain tumor, are urgently required. A major hurdle in the development of effective therapies is the impaired delivery of systemic therapies to tumor cells due to a specialized e...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Genovesi, Laura A, Puttick, Simon, Millar, Amanda, Kojic, Marija, Ji, Pengxiang, Lagendijk, Anne K, Brighi, Caterina, Bonder, Claudine S, Adolphe, Christelle, Wainwright, Brandon J
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099473/
https://ncbi.nlm.nih.gov/pubmed/33258962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa266
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