Vascular-derived SPARC and SerpinE1 regulate interneuron tangential migration and accelerate functional maturation of human stem cell-derived interneurons

Cortical interneurons establish inhibitory microcircuits throughout the neocortex and their dysfunction has been implicated in epilepsy and neuropsychiatric diseases. Developmentally, interneurons migrate from a distal progenitor domain in order to populate the neocortex – a process that occurs at a...

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Veröffentlicht in:eLife
Hauptverfasser: Genestine, Matthieu, Ambriz, Daisy, Crabtree, Gregg W, Dummer, Patrick, Molotkova, Anna, Quintero, Michael, Mela, Angeliki, Biswas, Saptarshi, Feng, Huijuan, Zhang, Chaolin, Canoll, Peter, Hargus, Gunnar, Agalliu, Dritan, Gogos, Joseph A, Au, Edmund
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2021
Schlagworte:
Developmental Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099424/
https://ncbi.nlm.nih.gov/pubmed/33904394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.56063
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