PHF8-promoted TOPBP1 demethylation drives ATR activation and preserves genome stability

The checkpoint kinase ATR [ATM (ataxia-telangiectasia mutated) and rad3-related] is a master regulator of DNA damage response. Yet, how ATR activity is regulated remains to be investigated. We report here that histone demethylase PHF8 (plant homeodomain finger protein 8) plays a key role in ATR acti...

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Publicat a:Sci Adv
Autors principals: Ma, Shuai, Cao, Cheng, Che, Shiyou, Wang, Yuejiao, Su, Dongxue, Liu, Shuai, Gong, Wenchen, Liu, Ling, Sun, Jixue, Zhao, Jiao, Wang, Qian, Song, Nan, Ge, Tong, Guo, Qiushi, Tian, Shanshan, Chen, Charlie Degui, Zhang, Tao, Wang, Ju, Ding, Xiang, Yang, Fuquan, Ying, Guoguang, Yang, Jie, Zhang, Kai, Zhu, Yi, Yao, Zhi, Yang, Na, Shi, Lei
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2021
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099190/
https://ncbi.nlm.nih.gov/pubmed/33952527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abf7684
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