GSK3ß inhibitor CHIR 99021 modulates cerebral organoid development through dose-dependent regulation of apoptosis, proliferation, differentiation and migration

Cerebral organoids generated from human pluripotent stem cells (hiPSCs) are unique in their ability to recapitulate human-specific neurodevelopmental events. They are capable of modeling the human brain and its cell composition, including human-specific progenitor cell types; ordered laminar compart...

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Veröffentlicht in:PLoS One
Hauptverfasser: Delepine, Chloe, Pham, Vincent A., Tsang, Hayley W. S., Sur, Mriganka
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2021
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8099055/
https://ncbi.nlm.nih.gov/pubmed/33951093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0251173
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