Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein

Pannexin 1 (PANX1) is a glycoprotein that forms large pore channels capable of passing ions and metabolites such as ATP for cellular communication. PANX1 has been implicated in many diseases including breast cancer and melanoma, where inhibition or deletion of PANX1 reduced the tumorigenic and metas...

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Vydáno v:Mol Biol Cell
Hlavní autoři: Nouri-Nejad, Daniel, O’Donnell, Brooke L., Patil, Chetan S., Sanchez-Pupo, Rafael E., Johnston, Danielle, Sayedyahossein, Samar, Jurcic, Kristina, Lau, Rebecca, Gyenis, Laszlo, Litchfield, David W., Jackson, Michael F., Gloor, Gregory B., Penuela, Silvia
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2021
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098850/
https://ncbi.nlm.nih.gov/pubmed/33405952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E19-10-0585
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