R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast

R-loops, the byproduct of DNA–RNA hybridization and the displaced single-stranded DNA (ssDNA), have been identified in bacteria, yeasts, and other eukaryotic organisms. The persistent presence of R-loops contributes to defects in DNA replication and repair, gene expression, and genomic integrity. R-...

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Udgivet i:Mol Biol Cell
Main Authors: Mishra, Prashant K., Chakraborty, Arijita, Yeh, Elaine, Feng, Wenyi, Bloom, Kerry S., Basrai, Munira A.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2021
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098821/
https://ncbi.nlm.nih.gov/pubmed/33147102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E20-06-0379
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