PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8(+) T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients

Tumor-reactive T cell exhaustion prevents the success of immune therapies. Pegilodecakin activates intratumoral CD8(+) T cells in mice and induces objective tumor responses in patients. Here we report that pegilodecakin induces hallmarks of CD8(+) T cell immunity in cancer patients, including elevat...

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Udgivet i:Cancer Cell
Main Authors: Naing, Aung, Infante, Jeffrey R., Papadopoulos, Kyriakos P., Chan, Ivan H., Shen, Cong, Ratti, Navneet P., Rojo, Bianca, Autio, Karen A., Wong, Deborah J., Patel, Manish R., Ott, Patrick A., Falchook, Gerald S., Pant, Shubham, Hung, Annie, Pekarek, Kara L., Wu, Victoria, Adamow, Matthew, McCauley, Scott, Mumm, John B., Wong, Phillip, Vlasselaer, Peter Van, Leveque, Joseph, Tannir, Nizar M., Oft, Martin
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098754/
https://ncbi.nlm.nih.gov/pubmed/30423297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2018.10.007
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