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Intermediates in allosteric equilibria of DnaK–ATP interactions with substrate peptides

Hsp70 molecular chaperones facilitate protein disaggregation and proper folding through iterative cycles of polypeptide binding and release that are allosterically coupled to ATP binding and hydrolysis. Hsp70s are ubiquitous and highly conserved across all of life; they bind ATP at an N-terminal nuc...

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Bibliografische gegevens
Gepubliceerd in:Acta Crystallogr D Struct Biol
Hoofdauteurs: Wang, Wei, Hendrickson, Wayne A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: International Union of Crystallography 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098474/
https://ncbi.nlm.nih.gov/pubmed/33950017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2059798321002436
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