High Frequency of TP53 Mutations in Juvenile Pilocytic Astrocytomas Indicates Role of TP53 in the Development of These Tumors

In adults, the TP53 tumor suppressor gene is frequently mutated in astrocytic brain tumors which is supposed to represent an early event in their development. In juvenile pilocytic and low‐grade astrocytomas, however, TP53 mutations have until now been reported as rare, which has led to the suggesti...

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Veröffentlicht in:Brain Pathol
Hauptverfasser: Hayes, Vanessa M., Dirven, Clemens M.F., Dam, Anke, Verlind, Edwin, Molenaar, Willemina M., Mooij, Jan Jakob A., Hofstra, Robert M.W., Buys, Charles H.C.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Publishing Ltd 2006
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098180/
https://ncbi.nlm.nih.gov/pubmed/10416986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.1999.tb00535.x
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