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Thrombin Aggravates Hypoxia/Reoxygenation Injury of Cardiomyocytes by Activating an Autophagy Pathway-Mediated by SIRT1

BACKGROUND: Acute myocardial infarction is the leading cause of mortality among adults worldwide. The present study aimed to investigate the role and mechanism of thrombin and SIRT1 in hypoxia/reoxygenation (H/R) injury. MATERIAL/METHODS: H9c2 cardiomyocytes were used to create an H/R model to simul...

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Bibliographic Details
Published in:Med Sci Monit
Main Authors: Wang, Xiaoning, Xu, Yunhe, Li, Lingbo, Lu, Weiwei
Format: Artigo
Language:Inglês
Published: International Scientific Literature, Inc. 2021
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098101/
https://ncbi.nlm.nih.gov/pubmed/33931577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.928480
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