An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer’s disease

Protein aggregation is the hallmark of neurodegeneration but the molecular mechanisms underlying late-onset Alzheimer’s disease (AD) remain unclear. Here we integrated transcriptomic, proteomic and epigenomic analyses of post-mortem human brains to identify molecular pathways involved in AD. RNA-seq...

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Pubblicato in:Nat Genet
Autori principali: Nativio, Raffaella, Lan, Yemin, Donahue, Greg, Sidoli, Simone, Berson, Amit, Srinivasan, Ananth R., Shcherbakova, Oksana, Amlie-Wolf, Alexandre, Nie, Ji, Cui, Xiaolong, He, Chuan, Wang, Li-San, Garcia, Benjamin A., Trojanowski, John Q., Bonini, Nancy M., Berger, Shelley L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8098004/
https://ncbi.nlm.nih.gov/pubmed/32989324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0696-0
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