Low-dose IL-34 has no effect on osteoclastogenesis but promotes osteogenesis of hBMSCs partly via activation of the PI3K/AKT and ERK signaling pathways

BACKGROUND: Inflammatory microenvironment is significant to the differentiation and function of mesenchymal stem cells (MSCs). It evidentially influences the osteoblastogenesis of MSCs. IL-34, a newly discovered cytokine, playing a key role in metabolism. However, the research on its functional role...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Xu, Jianxiang, Fu, Lifeng, Bai, Jinwu, Zhong, Huiming, Kuang, Zhihui, Zhou, Chengwei, Hu, Bin, Ni, Licheng, Ying, Li, Chen, Erman, Zhang, Wei, Wu, Jiaqi, Xue, Deting, Li, Weixu, Pan, Zhijun
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097863/
https://ncbi.nlm.nih.gov/pubmed/33947456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-021-02263-3
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