Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial

IMPORTANCE: Proactive therapeutic drug monitoring (TDM), defined as individualized drug dosing based on scheduled monitoring of serum drug levels, has been proposed as an alternative to standard therapy to maximize efficacy and safety of infliximab and other biological drugs. However, whether proact...

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Publicat a:JAMA
Autors principals: Syversen, Silje Watterdal, Goll, Guro Løvik, Jørgensen, Kristin Kaasen, Sandanger, Øystein, Sexton, Joseph, Olsen, Inge Christoffer, Gehin, Johanna Elin, Warren, David John, Brun, Marthe Kirkesæther, Klaasen, Rolf Anton, Karlsen, Lars Normann, Noraberg, Geir, Zettel, Camilla, Ljoså, Maud Kristine Aga, Haugen, Anne Julsrud, Njålla, Rune Johan, Bruun, Trude Jannecke, Seeberg, Kathrine Aglen, Michelsen, Brigitte, Strand, Eldri Kveine, Skorpe, Svanaug, Blomgren, Ingrid Marianne, Bragnes, Yngvill Hovde, Dotterud, Christian Kvikne, Thune, Turid, Ystrøm, Carl Magnus, Torp, Roald, Mielnik, Pawel, Mørk, Cato, Kvien, Tore K., Jahnsen, Jørgen, Bolstad, Nils, Haavardsholm, Espen A.
Format: Artigo
Idioma:Inglês
Publicat: American Medical Association 2021
Matèries:
Original Investigation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097498/
https://ncbi.nlm.nih.gov/pubmed/33944876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2021.4172
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