Metabolic Survival Adaptations of Plasmodium falciparum Exposed to Sublethal Doses of Fosmidomycin

The malaria parasite Plasmodium falciparum contains the apicoplast organelle that synthesizes isoprenoids, which are metabolites necessary for posttranslational modification of Plasmodium proteins. We used fosmidomycin, an antibiotic that inhibits isoprenoid biosynthesis, to identify mechanisms that...

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Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Tewari, Shivendra G., Rajaram, Krithika, Swift, Russell P., Reifman, Jaques, Prigge, Sean T., Wallqvist, Anders
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2021
Gaiak:
Mechanisms of Action: Physiological Effects
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097461/
https://ncbi.nlm.nih.gov/pubmed/33495219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02392-20
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