Electrostatic-Mediated Affinity Tuning of Lysostaphin Accelerates Bacterial Lysis Kinetics and Enhances In Vivo Efficacy

Drug-resistant bacterial pathogens are a serious threat to global health, and antibacterial lysins are at the forefront of innovative treatments for these life-threatening infections. While lysins’ general mechanism of action is well understood, the design principles that might enable engineering of...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Zhao, Hongliang, Eszterhas, Susan, Furlon, Jacob, Cheng, Hao, Griswold, Karl E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2021
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097437/
https://ncbi.nlm.nih.gov/pubmed/33468459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02199-20
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