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Gene-environment dependencies lead to collider bias in models with polygenic scores

The application of polygenic scores has transformed our ability to investigate whether and how genetic and environmental factors jointly contribute to the variation of complex traits. Modelling the complex interplay between genes and environment, however, raises serious methodological challenges. He...

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Bibliografische gegevens
Gepubliceerd in:Sci Rep
Hoofdauteurs: Akimova, Evelina T., Breen, Richard, Brazel, David M., Mills, Melinda C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097011/
https://ncbi.nlm.nih.gov/pubmed/33947934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89020-x
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