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Gene-environment dependencies lead to collider bias in models with polygenic scores

The application of polygenic scores has transformed our ability to investigate whether and how genetic and environmental factors jointly contribute to the variation of complex traits. Modelling the complex interplay between genes and environment, however, raises serious methodological challenges. He...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Akimova, Evelina T., Breen, Richard, Brazel, David M., Mills, Melinda C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8097011/
https://ncbi.nlm.nih.gov/pubmed/33947934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-89020-x
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