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Polygenic risk scores: a biased prediction?

A new study highlights the biases and inaccuracies of polygenic risk scores (PRS) when predicting disease risk in individuals from populations other than those used in their derivation. The design bias of workhorse tools used for research, particularly genotyping arrays, contributes to these distort...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genome Med
Prif Awduron: De La Vega, Francisco M., Bustamante, Carlos D.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2018
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6309089/
https://ncbi.nlm.nih.gov/pubmed/30591078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-018-0610-x
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