Downregulation of Glutamine Synthetase, not glutaminolysis, is responsible for glutamine addiction in Notch1‐driven acute lymphoblastic leukemia

The cellular receptor Notch1 is a central regulator of T‐cell development, and as a consequence, Notch1 pathway appears upregulated in > 65% of the cases of T‐cell acute lymphoblastic leukemia (T‐ALL). However, strategies targeting Notch1 signaling render only modest results in the clinic due to...

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Veröffentlicht in:Mol Oncol
Hauptverfasser: Nguyen, Tra Ly, Nokin, Marie‐Julie, Terés, Silvia, Tomé, Mercedes, Bodineau, Clément, Galmar, Oriane, Pasquet, Jean‐Max, Rousseau, Benoit, van Liempd, Sebastian, Falcon‐Perez, Juan Manuel, Richard, Elodie, Muzotte, Elodie, Rezvani, Hamid‐Reza, Priault, Muriel, Bouchecareilh, Marion, Redonnet‐Vernhet, Isabelle, Calvo, Julien, Uzan, Benjamin, Pflumio, Françoise, Fuentes, Patricia, Toribio, Maria L., Khatib, Abdel‐Majid, Soubeyran, Pierre, Murdoch, Piedad del Socorro, Durán, Raúl V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2021
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096784/
https://ncbi.nlm.nih.gov/pubmed/33314742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12877
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