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Metabolic Implications of Non-Electrogenic ATP/ADP Exchange in Cancer Cells: A Mechanistic Basis for the Warburg Effect
In post-mitotic cells, mitochondrial ATP/ADP exchange occurs by the adenine nucleotide translocator (ANT). Driven by membrane potential (ΔΨ), ANT catalyzes electrogenic exchange of ATP(4−) for ADP(3−), leading to higher ATP/ADP ratios in the cytosol than mitochondria. In cancer cells, ATP/ADP exchan...
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| Publicado no: | Biochim Biophys Acta Bioenerg |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8096716/ https://ncbi.nlm.nih.gov/pubmed/33722515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbabio.2021.148410 |
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