Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies

Tumours with mutations in the BRCA1/BRCA2 genes have impaired double-stranded DNA break repair, compromised replication fork protection and increased sensitivity to replication blocking agents, a phenotype collectively known as ‘BRCAness’. Tumours with a BRCAness phenotype become dependent on altern...

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Publicado en:Nucleic Acids Res
Autores principales: Stok, Colin, Kok, Yannick P, van den Tempel, Nathalie, van Vugt, Marcel A T M
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096281/
https://ncbi.nlm.nih.gov/pubmed/33744950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab151
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