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Shaping the BRCAness mutational landscape by alternative double-strand break repair, replication stress and mitotic aberrancies
Tumours with mutations in the BRCA1/BRCA2 genes have impaired double-stranded DNA break repair, compromised replication fork protection and increased sensitivity to replication blocking agents, a phenotype collectively known as ‘BRCAness’. Tumours with a BRCAness phenotype become dependent on altern...
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| I publikationen: | Nucleic Acids Res |
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| Huvudupphovsmän: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Oxford University Press
2021
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8096281/ https://ncbi.nlm.nih.gov/pubmed/33744950 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab151 |
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