Crystal structure and functional implication of a bacterial cyclic AMP–AMP–GMP synthetase

Mammalian cyclic GMP-AMP synthase (cGAS) and its homologue dinucleotide cyclase in Vibrio cholerae (VcDncV) produce cyclic dinucleotides (CDNs) that participate in the defense against viral infection. Recently, scores of new cGAS/DncV-like nucleotidyltransferases (CD-NTases) were discovered, which p...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Ko, Tzu-Ping, Wang, Yu-Chuan, Tsai, Chia-Ling, Yang, Chia-Shin, Hou, Mei-Hui, Chen, Yeh
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8096243/
https://ncbi.nlm.nih.gov/pubmed/33836064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkab165
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