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Promoter Hypermethylation of the DNA Repair Gene O (6)‐Methylguanine‐DNA Methyltransferase is an Independent Predictor of Shortened Progression Free Survival in Patients with Low‐grade Diffuse Astrocytomas
The O(6)‐methylguanine‐DNA methyltransferase (MGMT) plays a major role in repairing DNA damage from alkylating agents. In several human neoplasms including low‐grade diffuse astrocytomas, promoter hypermethylation of MGMT has been shown to correlate with an increased frequency of p53 mutation. In th...
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| 出版年: | Brain Pathol |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Blackwell Publishing Ltd
2006
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8095943/ https://ncbi.nlm.nih.gov/pubmed/12744471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2003.tb00017.x |
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