Nopp140-chaperoned 2’-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity

Spliceosomal small nuclear RNAs (snRNAs) are modified by small Cajal body (CB) specific ribonucleoproteins (scaRNPs) to ensure snRNP biogenesis and pre-mRNA splicing. However, the function and subcellular site of snRNA modification are largely unknown. We show that CB localization of the protein Nop...

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Detalhes bibliográficos
Publicado no:bioRxiv
Main Authors: Bizarro, Jonathan, Deryusheva, Svetlana, Wacheul, Ludivine, Gupta, Varun, Ernst, Felix G.M., Lafontaine, Denis L.J., Gall, Joseph G., Meier, U. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095195/
https://ncbi.nlm.nih.gov/pubmed/33948588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.04.29.441821
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