Nopp140-chaperoned 2’-O-methylation of small nuclear RNAs in Cajal bodies ensures splicing fidelity

Spliceosomal small nuclear RNAs (snRNAs) are modified by small Cajal body (CB) specific ribonucleoproteins (scaRNPs) to ensure snRNP biogenesis and pre-mRNA splicing. However, the function and subcellular site of snRNA modification are largely unknown. We show that CB localization of the protein Nop...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:bioRxiv
Prif Awduron: Bizarro, Jonathan, Deryusheva, Svetlana, Wacheul, Ludivine, Gupta, Varun, Ernst, Felix G.M., Lafontaine, Denis L.J., Gall, Joseph G., Meier, U. Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cold Spring Harbor Laboratory 2021
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095195/
https://ncbi.nlm.nih.gov/pubmed/33948588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2021.04.29.441821
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