Potent preclinical activity of HexaBody-DR5/DR5 in relapsed and/or refractory multiple myeloma

Apoptosis induction by death receptor (DR)-specific agonistic antibodies is a potentially effective antitumor therapy. Nonetheless, to date, all conventional DR-targeting antibodies that induce apoptosis via FcγR-dependent DR clustering failed to show clinical efficacy. HexaBody-DR5/DR5 (GEN1029) ha...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: van der Horst, Hilma J., Gelderloos, Anne T., Chamuleau, Martine E. D., Breij, Esther C. W., Zweegman, Sonja, Nijhof, Inger S., Overdijk, Marije B., Mutis, Tuna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2021
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095144/
https://ncbi.nlm.nih.gov/pubmed/33885752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2020003731
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