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Top1-PARP1 association and beyond: from DNA topology to break repair
Selective trapping of human topoisomerase 1 (Top1) on the DNA (Top1 cleavage complexes; Top1cc) by specific Top1-poisons triggers DNA breaks and cell death. Poly(ADP-ribose) polymerase 1 (PARP1) is an early nick sensor for trapped Top1cc. New mechanistic insights have been developed in recent years...
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| Publicat a: | NAR Cancer |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8095074/ https://ncbi.nlm.nih.gov/pubmed/33981998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/narcan/zcab003 |
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