Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination

Metastasis is the primary cause of cancer mortality, and cancer frequently metastasizes to the liver. It is not clear whether liver immune tolerance mechanisms contribute to cancer outcomes. We report that liver metastases diminish immunotherapy efficacy systemically in patients and preclinical mode...

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Publicado no:Nat Med
Main Authors: Yu, Jiali, Green, Michael D., Li, Shasha, Sun, Yilun, Journey, Sara N., Choi, Jae Eun, Rizvi, Syed Monem, Qin, Angel, Waninger, Jessica J., Lang, Xueting, Chopra, Zoey, Naqa, Issam El, Zhou, Jiajia, Bian, Yingjie, Jiang, Long, Tezel, Alangoya, Skvarce, Jeremy, Achar, Rohan K., Sitto, Merna, Rosen, Benjamin S., Su, Fengyun, Narayanan, Sathiya P., Cao, Xuhong, Wei, Shuang, Szeliga, Wojciech, Vatan, Linda, Mayo, Charles, Morgan, Meredith A., Schonewolf, Caitlin A., Cuneo, Kyle, Kryczek, Ilona, Ma, Vincent T., Lao, Christopher D., Lawrence, Theodore S., Ramnath, Nithya, Wen, Fei, Chinnaiyan, Arul M., Cieslik, Marcin, Alva, Ajjai, Zou, Weiping
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8095049/
https://ncbi.nlm.nih.gov/pubmed/33398162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41591-020-1131-x
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