PCR‐ and Restriction Endonuclease‐Based Detection of IDH1 Mutations

Hotspot mutations in codon 132 of the gene encoding isocitrate dehydrogenase 1 (IDH1) have emerged as the most frequent DNA alteration in astrocytomas, oligodendrogliomas and oligoastrocytomas. These mutations have been shown to be of significant diagnostic and prognostic value. So far, assessment o...

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Bibliografiske detaljer
Udgivet i:Brain Pathol
Main Authors: Meyer, Jochen, Pusch, Stefan, Balss, Jörg, Capper, David, Mueller, Wolf, Christians, Arne, Hartmann, Christian, Von Deimling, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2009
Fag:
Technical Advances
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094690/
https://ncbi.nlm.nih.gov/pubmed/19744125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2009.00327.x
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