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Cell Cycle Elongation Impairs Proliferation of Cerebellar Granule Cell Precursors in the Ts65Dn Mouse, an Animal Model for Down Syndrome

Mental retardation, the hallmark of Down syndrome (DS), has been attributed to the reduced number of neurons populating the DS brain. The Ts65Dn mouse model of DS displays several anomalies analogous to those in individuals with DS, including neurogenesis impairment. The goal of the current study wa...

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Bibliografiske detaljer
Udgivet i:Brain Pathol
Main Authors: Contestabile, Andrea, Fila, Tatiana, Bartesaghi, Renata, Ciani, Elisabetta
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094641/
https://ncbi.nlm.nih.gov/pubmed/18482164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1750-3639.2008.00168.x
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