Absence of the CXCR4 antagonist EPI-X4 from pharmaceutical human serum albumin preparations

BACKGROUND: Endogenous Peptide Inhibitor of CXCR4 (EPI-X4) is a natural antagonist of the CXC chemokine receptor 4 (CXCR4). EPI-X4 is a 16-mer peptide that is released from human serum albumin (HSA) by acidic aspartic proteases such as Cathepsin D and E. Since human serum albumin (HSA) is an importa...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Gilg, Andrea, Harms, Mirja, Olari, Lia-Raluca, Urbanowitz, Ann-Kathrin, Bonig, Halvard, Münch, Jan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094565/
https://ncbi.nlm.nih.gov/pubmed/33941197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-021-02859-6
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