8-Substituted Triazolobenzodiazepines: In Vitro and In Vivo Pharmacology in Relation to Structural Docking at the α1 Subunit-Containing GABA(A) Receptor

In order to develop improved anxiolytic drugs, 8-substituted analogs of triazolam were synthesized in an effort to discover compounds with selectivity for α2/α3 subunit-containing GABA(A) subtypes. Two compounds in this series, XLi-JY-DMH (6-(2-chlorophenyl)-8-ethynyl-1-methyl-4H-benzo [f][1,2,4]tri...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Golani, Lalit K., Platt, Donna M., Rüedi-Bettschen, Daniela, Edwanker, Chitra, Huang, Shenming, Poe, Michael M., Furtmüller, Roman, Sieghart, Werner, Cook, James M., Rowlett, James K.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8094182/
https://ncbi.nlm.nih.gov/pubmed/33959005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2021.625233
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