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Inhibition of COX-2 Impairs Colon Cancer Liver Metastasis through Reduced Stromal Cell Reaction
Liver colonization is initiated through the interplay between tumor cells and adhesion molecules present in liver sinusoidal endothelial cells (LSECs). This crosstalk stimulates tumor COX-2 upregulation and PGE(2) secretion. To elucidate the role of the LSEC intercellular adhesion molecule-1 (ICAM-1...
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| Publicado no: | Biomol Ther (Seoul) |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Korean Society of Applied Pharmacology
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8094073/ https://ncbi.nlm.nih.gov/pubmed/33455946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4062/biomolther.2020.160 |
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