Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system

The preclinical development of microRNA-based gene therapies for inherited neurodegenerative diseases is accompanied by translational challenges. Due to the inaccessibility of the brain to periodically evaluate therapy effects, accessible and reliable biomarkers indicative of dosing, durability and...

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Podrobná bibliografie
Vydáno v:Brain Commun
Hlavní autoři: Sogorb-Gonzalez, Marina, Vendrell-Tornero, Carlos, Snapper, Jolanda, Stam, Anouk, Keskin, Sonay, Miniarikova, Jana, Spronck, Elisabeth A, de Haan, Martin, Nieuwland, Rienk, Konstantinova, Pavlina, van Deventer1, Sander J, Evers, Melvin M, Vallès, Astrid
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2021
Témata:
Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093922/
https://ncbi.nlm.nih.gov/pubmed/34704020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcab054
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