Secreted therapeutics: monitoring durability of microRNA-based gene therapies in the central nervous system

The preclinical development of microRNA-based gene therapies for inherited neurodegenerative diseases is accompanied by translational challenges. Due to the inaccessibility of the brain to periodically evaluate therapy effects, accessible and reliable biomarkers indicative of dosing, durability and...

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Detalhes bibliográficos
Publicado no:Brain Commun
Main Authors: Sogorb-Gonzalez, Marina, Vendrell-Tornero, Carlos, Snapper, Jolanda, Stam, Anouk, Keskin, Sonay, Miniarikova, Jana, Spronck, Elisabeth A, de Haan, Martin, Nieuwland, Rienk, Konstantinova, Pavlina, van Deventer1, Sander J, Evers, Melvin M, Vallès, Astrid
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093922/
https://ncbi.nlm.nih.gov/pubmed/34704020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcab054
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