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Structure basis for AA98 inhibition on the activation of endothelial cells mediated by CD146
CD146 is an adhesion molecule that plays important roles in angiogenesis, cancer metastasis, and immune response. It exists as a monomer or dimer on the cell surface. AA98 is a monoclonal antibody that binds to CD146, which abrogates the activation of CD146-mediated signaling pathways and shows inhi...
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| Publicat a: | iScience |
|---|---|
| Autors principals: | , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8093899/ https://ncbi.nlm.nih.gov/pubmed/33997697 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102417 |
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