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Population distributions from native mass spectrometry titrations reveal nearest-neighbor cooperativity in the ring-shaped oligomeric protein TRAP

Allostery pervades macromolecular function and drives cooperative binding of ligands to macromolecules. To decipher the mechanisms of cooperative ligand binding it is necessary to define, at a microscopic level, the thermodynamic consequences of binding of each ligand to its energetically coupled si...

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Detalhes bibliográficos
Publicado no:Biochemistry
Main Authors: Holmquist, Melody L., Ihms, Elihu C., Gollnick, Paul, Wysocki, Vicki H., Foster, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8093080/
https://ncbi.nlm.nih.gov/pubmed/32558551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.0c00352
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