Identification and Characterization of Two Novel ISCR1-Associated Genes, dfrA42 and dfrA43, Encoding Trimethoprim-Resistant Dihydrofolate Reductases

Two novel ISCR1-associated dfr genes, dfrA42 and dfrA43, were identified from trimethoprim (TMP)-resistant Proteus strains and were shown to confer high levels of TMP resistance (MIC, ≥1,024 mg/liter) when cloned into Escherichia coli isolates. These genes were hosted by complex class 1 integrons, s...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Li, Ling, Zhang, Mengge, Wang, Wenjia, Xia, Ruirui, Ma, Yanan, Wei, Xin, Wang, Xinhua, Sun, Xiaomin, Xie, Xiaohong, Xie, Shiling, Wang, Mingyu, Xu, Hai
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2021
Fag:
Mechanisms of Resistance
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092886/
https://ncbi.nlm.nih.gov/pubmed/33593833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02010-20
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