Foot-and-Mouth Disease Virus Structural Protein VP1 Destroys the Stability of the TPL2 Trimer by Degradation of TPL2 To Evade Host Antiviral Immunity

Tumor progression locus 2 (TPL2) is a serine/threonine kinase that belongs to the mitogen-activated protein 3 kinase (MAP3K) family, and it plays an important role in pathogen infection. The trimer complex of TPL2, p105, and ABIN2 is essential for maintenance of TPL2 steady-state levels and host cel...

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Vydáno v:J Virol
Hlavní autoři: Zhang, Keshan, Yan, Minghao, Hao, Junhong, Shen, Chaochao, Zhu, Zixiang, Zhang, Dajun, Hou, Jing, Xu, Guowei, Li, Dan, Zheng, Haixue, Liu, Xiangtao
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2021
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8092693/
https://ncbi.nlm.nih.gov/pubmed/33361430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02149-20
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